TB-500 is a synthetic analogue of Thymosin Beta-4, one of the most abundant actin-sequestering proteins in the human body. First isolated from the thymus gland, Thymosin Beta-4 is a 43-amino-acid peptide present in virtually all cell types, where it plays a fundamental role in cytoskeletal dynamics, cell motility, and tissue repair.

TB-500 10 mg — Research-Grade Thymosin Beta-4

The peptide’s central active domain — the sequence LKKTETQ — is thought to be responsible for its cell-migratory and anti-inflammatory properties, making TB-500 a cornerstone of regenerative biology research.

Product Specifications

Research Background

TB-500 exerts its biological effects primarily through the actin-cytoskeleton axis. By binding to and sequestering G-actin monomers, it modulates actin polymerisation — the process by which cells build their internal structural framework. This mechanism directly influences cell migration, division, and signalling.

Cell migration and wound healing — TB-500 promotes the directional movement of cells toward sites of damage, a process critical to tissue repair. Its LKKTETQ domain is thought to be the key driver of this migratory activity.

Anti-inflammatory effects — Preclinical studies report that TB-500 reduces pro-inflammatory cytokine expression, suggesting a role in modulating the inflammatory phase of tissue repair.

Angiogenesis — TB-500 has been shown to promote new blood vessel formation in preclinical models, which is essential for supplying nutrients and oxygen to healing tissues.

Extracellular matrix remodelling — Research indicates TB-500 may upregulate laminin and other ECM proteins involved in tissue scaffolding and structural repair.

Key research areas include cardiac tissue repair (post-ischaemic models), dermal wound healing and burn models, systemic inflammation, corneal and ocular repair, and musculoskeletal recovery studies.

Reconstitution

Reconstitute with 1–2 ml of bacteriostatic water. A 10 mg vial reconstituted with 2 ml yields 5 mg/ml (500 mcg per 0.1 ml). TB-500 dissolves readily within 5–10 minutes. Store at 2–8°C and use within 2–3 weeks — TB-500 is slightly less stable post-reconstitution than smaller peptides. Full guide: How to Reconstitute Peptides.

Quality Assurance

Every batch undergoes independent third-party HPLC and mass spectrometry testing. A batch-specific Certificate of Analysis (CoA) confirms ≥99% purity and correct molecular identity. All inventory stored at -20°C in industrial-grade freezers.

Related Products

TB-500 is frequently studied alongside BPC-157 for complementary recovery pathway research. We offer a pre-mixed TB-500 + BPC-157 Blend (5/5 mg) and capsule-form TB-4 FRAG + BPC-157 ARG. See also: TB-500 vs BPC-157: Key Differences. Browse our full Recovery & Repair range.

All products sold by BioLab Peptides are intended strictly for laboratory and research purposes. Not for human or veterinary consumption.