5-Amino-1MQ Capsules – NNMT Inhibitor for Metabolic Research
5-Amino-1MQ is a cell-permeable, selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and plays a regulatory role in cellular energy metabolism. Unlike peptides, 5-Amino-1MQ is a small molecule, but it has become a key compound in metabolic research alongside peptide-based weight management tools.
Research Background
NNMT and fat metabolism – NNMT is highly expressed in white adipose tissue. Research shows that NNMT inhibition reduces fat cell size, increases energy expenditure, and shifts cellular metabolism toward a more thermogenic profile. 5-Amino-1MQ is one of the most studied selective NNMT inhibitors for this purpose.
NAD+ salvage pathway – NNMT consumes nicotinamide (a NAD+ precursor) through methylation. By inhibiting NNMT, 5-Amino-1MQ preserves the NAD+ salvage pathway, potentially increasing intracellular NAD+ availability. This connects metabolic research to the broader longevity and sirtuin biology field.
No CNS effects – 5-Amino-1MQ does not cross the blood-brain barrier in preclinical models, confining its activity to peripheral tissues. This peripheral selectivity is useful for researchers studying metabolic pathways without CNS confounders.
Related Products
For complementary metabolic research, see AOD-9604, Fragment 176-191, MOTS-c, and Lipotropin. Browse Weight Management.




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