Matrixyl 20 mg – Collagen-Stimulating Lipopeptide
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a synthetic lipopeptide developed by Sederma. The core sequence KTTKS is a fragment of type I procollagen that acts as a matrikine – a peptide fragment of extracellular matrix proteins that signals cells to produce new matrix components.
Research Background
Collagen synthesis – Matrixyl has been shown to stimulate production of collagen types I, III, and IV in fibroblast models. The KTTKS sequence mimics a collagen breakdown fragment, effectively signalling fibroblasts that matrix repair is needed.
Fibronectin production – Beyond collagen, Matrixyl stimulates fibronectin synthesis, a glycoprotein critical for cell adhesion, migration, and wound healing in the extracellular matrix.
Palmitoyl modification – The palmitic acid chain enhances membrane permeability and stability, allowing the peptide to cross cell membranes and reach intracellular targets more effectively than the unmodified KTTKS sequence alone.
Related Products
For complementary skin biology research, see GHK-Cu (gene expression modulation), SNAP-8 (neuromuscular peptide), and Melanotan 2 (melanogenesis). Browse Skin & Tanning.
For research use only. Not for human or veterinary consumption.




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