Semax 50 mg

Buy Semax 50mg UK – ACTH-Derived Nootropic Peptide

Semax is a synthetic analogue of the ACTH (4-10) fragment of adrenocorticotropic hormone. It retains the neurotrophic activity of ACTH without the hormonal (adrenal-stimulating) effects, making it a clean CNS research tool that does not elevate cortisol. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences), Semax has been used in Russia for decades and has accumulated a substantial published research record.

Product Specifications

Product Name	Semax 50mg
Molecular Formula	C39H53N9O10S
Molecular Weight	813.95 g/mol
CAS Number	80714-61-0
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro (7 aa)
Purity	≥99% (HPLC & MS)

Research Background

BDNF upregulation. Semax is one of the most-studied peptides for brain-derived neurotrophic factor modulation. BDNF is a master regulator of neuronal survival, synaptic plasticity, and long-term memory, and its upregulation is the primary studied mechanism for Semax’s nootropic effects.

Neuroprotection. Semax has been investigated in ischaemic brain injury research models, where studies reported reduced infarct volume and preserved neuronal viability. It is approved as a stroke treatment in Russia (where it was developed), though not in the UK or US.

Cognitive enhancement research. Published studies have examined effects on attention, working memory, and information processing, potentially mediated through dopaminergic and serotonergic pathway modulation alongside the BDNF mechanism.

NGF and neurotrophins. Beyond BDNF, Semax has been studied for effects on nerve growth factor (NGF) and other neurotrophic factor expression profiles.

Semax vs N-Acetyl Semax

The standard Semax (this product) is the unmodified ACTH 4-10 analogue. N-Acetyl Semax adds an acetyl group to the N-terminus, which extends half-life by protecting against aminopeptidase degradation and improves blood-brain barrier penetration. For most comparative nootropic research, standard Semax is the reference compound; N-Acetyl Semax is used when longer duration of action is needed.

Related Products

Also available as Semax Nasal Spray 50mg and N-Acetyl Semax 50mg. Compare with Selank (anxiolytic nootropic from the same research group). Browse Cognitive & Nootropic peptides.

Frequently Asked Questions

Is Semax 50mg the standard research dose?
50mg per vial is the most common laboratory supply format for Semax. Researchers typically reconstitute and aliquot for their specific protocol requirements. Published research uses a wide range of concentrations depending on model and mechanism studied.

What is the difference between Semax and N-Acetyl Semax?
N-Acetyl Semax adds an acetyl group to the N-terminus, extending half-life and improving BBB penetration. Standard Semax is the reference compound used in most published studies.

Can Semax be used as a nasal spray?
Yes, Semax is most commonly researched as a nasal spray in Russian clinical literature. We stock both the lyophilised powder (this product) and a pre-formulated Semax Nasal Spray.

For research and laboratory use only. Not for human or veterinary consumption.