MOTS-c 10 mg – Mitochondrial-Derived Metabolic Peptide
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome (12S rRNA gene), discovered by Dr. Changhan David Lee at the University of Southern California in 2015. It is one of the first identified mitochondrial-derived peptides (MDPs) and represents a paradigm shift in understanding how mitochondria communicate with the nucleus and regulate systemic metabolism.
Research Background
AMPK activation – MOTS-c activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy balance. AMPK activation promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis, positioning MOTS-c as a key research tool for metabolic pathway studies.
Exercise mimetic – MOTS-c levels increase during exercise in humans. Research suggests it may partially mediate the metabolic benefits of physical activity, making it a subject of interest in exercise biology and sedentary-lifestyle metabolic research.
Insulin sensitivity – Preclinical studies report improved insulin sensitivity and glucose homeostasis in models treated with MOTS-c, linking mitochondrial signalling to systemic metabolic regulation.
Ageing biology – MOTS-c levels decline with age. This decline parallels the deterioration of metabolic function, suggesting a role in age-related metabolic dysregulation and making it relevant to longevity research alongside Epithalon and SS-31.
Related Products
For complementary metabolic research, see SS-31 (mitochondrial targeting), Epithalon (longevity), and 5-Amino-1MQ. Browse Anti-Ageing & Longevity and Weight Management.




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