Kisspeptin-10 Spray 5 mg – Reproductive Neuroendocrine Peptide
Kisspeptin-10 is the shortest biologically active fragment of the Kisspeptin family, retaining full agonist activity at the Kisspeptin receptor (KISS1R/GPR54). The Kisspeptin system was identified in the early 2000s as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis, making it one of the most significant discoveries in reproductive neuroendocrinology.
Research Background
GnRH pulse regulation – Kisspeptin neurons in the hypothalamus directly innervate and stimulate GnRH neurons, controlling the pulsatile release of GnRH that drives luteinising hormone (LH) and follicle-stimulating hormone (FSH) secretion. This makes Kisspeptin-10 a precise tool for studying HPG axis dynamics.
Puberty and fertility research – Loss-of-function mutations in the KISS1 or KISS1R genes cause hypogonadotropic hypogonadism and absent puberty in humans, establishing Kisspeptin as essential for reproductive maturation. Research models use Kisspeptin-10 to study these pathways.
Neuroendocrine signalling – Beyond reproduction, Kisspeptin neurons integrate metabolic, circadian, and stress signals, making Kisspeptin-10 relevant to broader neuroendocrine crosstalk research.
Related Products
For complementary reproductive research, see PT-141, GonadoMax, and Alarelin. Browse Sexual Health.
For research use only. Not for human or veterinary consumption.




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