PT-141 10 mg | Melanocortin Receptor Research Peptide
PT-141 (Bremelanotide) is a cyclic heptapeptide and selective melanocortin-4 receptor (MC4R) agonist. Originally developed as a derivative of Melanotan II, PT-141 was found to act on central nervous system pathways governing sexual arousal — a mechanism fundamentally different from peripheral vasodilators like PDE5 inhibitors.
Product Specifications
| Molecular Weight | 1,025.18 g/mol |
| CAS | 189691-06-3 |
| Structure | Cyclic heptapeptide (lactam bridge) |
| Purity | ≥99% (HPLC & MS) |
Research Background
Central mechanism : PT-141 activates melanocortin-3 and melanocortin-4 receptors (MC3R/MC4R) in the hypothalamus, triggering downstream signalling that influences sexual arousal pathways. This central mechanism distinguishes it from PDE5 inhibitors that act peripherally on vascular smooth muscle.
Preclinical sexual function studies : PT-141 has been investigated in both male and female preclinical models, where it demonstrated effects on sexual motivation and arousal independent of hormonal status — an unusual profile among compounds studied for sexual function.
Melanocortin system research : Beyond sexual function, the melanocortin receptor system is implicated in energy homeostasis, inflammation, and neuroprotection, making PT-141 a versatile research tool for MC4R pathway studies.
Related Products
Also available as PT-141 Nasal Spray. See also Melanotan 2 (parent compound), Kisspeptin-10, and Tadalafil. Browse Sexual Health peptides.




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